When engaging in intense physical activity, your mitochondria are not damaged, but rather pushed to their limit. They have reached their maximum capacity to generate ATP in the presence of oxygen, causing them to be unable to meet your body's energy needs. It's similar to driving a car with the accelerator pressed all the way down, unable to go any faster, resulting in the activation of an alternative pathway.
The secondary energy production method, glycolysis, is a rapid yet inefficient process that utilizes abundant resources and doesn't produce carbon dioxide. While it generates lactate, leading to reductive stress, it's not a significant issue in this context, as it's a temporary backup system that won't be employed for extended periods. Its brief usage has limited consequences and even offers several health advantages.
The state of mitochondrial physiology that Warburg accurately identified occurs when your body has enough oxygen and the mitochondria are not maxed out, yet still uses the backup glycolysis pathway. This, my friends, is also called cancer metabolism.
It gives the false impression that cancer is using glucose to supply its metabolic needs for energy, but it is merely an optical illusion. Even brilliant research scientists like Dr. Tom Seyfried, a leading expert on the theory of cancer as a metabolic disease, are confused about this. I would love to interview Tom about this, but he and most are so conformationally biased, they refuse to reconsider there position on this point.
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